Graphics

Highly Potent Antimalarial Compounds Derived from the GlaxoSmithKline Tres Cantos Arylpyrroles. Researchers made several molecules, and measured the ability of those molecules to kill the parasite that causes malaria. Many people have contributed from around the world (47 authors, 8 countries) using a publicly-available online "labbook". The molecules were very capable of killing the parasite, but didn’t quite perform well enough in a malaria-infected mouse to proceed any further.

Humans differ in their personal microbial cloud. We each give off millions of bacteria from our human microbiome to the air around us every day, and that cloud of bacteria can be traced back to an individual. To test this, researchers sequenced microbes from the air surrounding 11 different people in a sanitized experimental chamber.

Discovery and resupply of pharmacologically active plant-derived natural products: A review. While natural product-based drug discovery and development represents a complex endeavor demanding a highly integrated interdisciplinary approach, the recent scientific developments, technological advances, and research trends clearly indicate that natural products will be among the most important sources of new drugs also in the future.